The experiments that German chemist Hermann Emil Fischer conducted on amino acids in 1900 were certainly exciting. Together with his work group, he succeeded in synthesizing around 100 peptides, each comprising of up to 17 amino acids.The American biochemist Vincent du Vigneaud finally managed to produce the first synthetic polypeptide hormone in 1953. It was oxytocin, which plays an important role during childbirth. But it took another decade until Robert Bruce Merrifield achieved his breakthrough by designing an automatic peptide synthesis process, which he called solid-phase synthesis. It enabled the manufacture of synthetic insulin and other hormones.But this was by no means the end of the peptide story.
During the 1970s, Soviet scientists Vladimir Khavinson and VyacheslavMorozoy developed certain peptide bioregulators. What makes them special is their capacity to help the body maintain its natural regeneration function.Their work was based on research conducted at the Military Medical Academy in St. Petersburg, which aimed to preserve the physical capacities of Soviet troops despite exposure to radiation trauma or hypothermia.
“When our research started, the military was experimenting with laser beams that burned the retina. We were asked to develop a drug that protected humans from battle lasers,” says Professor Vladimir Khavinson, a retired physician with the rank of Colonel. “To do this, we isolated peptides from the retinas of calves and initially used the preparation we obtained on rabbits, before moving on to clinical trials. We realized that our drug was able to reduce the destructive impact of the laser on the retina, and that it also precipitated regeneration.” Nowhere else in the world – neither in the United States or in Europe – had a drug of this caliber been developed. It therefore ranked as a major accomplishment for Russia. Not only did it reduce the deterioration in vision, it also managed to restore eyesight within two weeks. Khavinson explains: “Further research revealed that the processes that unfold during aging are similar to stress situations: protein synthesis is inhibited in various organs and tissues, especially in the brain and in the immune and hormone systems.”
Khavinson Vladimir was born in 1946 in Cottbus, in the former GDR (German Democratic Republic). His scientific work focuses on gerontology, biochemistry and immunology. He is an Honored Scientist of the Russian Federation, holder of the Prize of the Council of Ministers of the USSR, professor, reader and doctor of medicine, Corresponding Member of the Russian Academy of Medical Sciences, Director of the Chair of Gerontology and Geriatrics at the Northwest State University of Metschnikov and Honored Inventor of the RSFSR (since 1998).
Khavinson is Director of the St. Petersburg Institute for Bio-Regulation and Gerontology, President of the European Regional Chapter of the International Association of Gerontology and Geriatrics (IAGG) since 2011, Vice President of the Gerontology Association of the Russian Academy of Sciences and Chief Gerontologist in St. Petersburg.
Nominated for the Nobel Prize in 2010, he has authored 775 scientific publications and can present 194 inventors certificates and patents in the field of gerontology, biotechnology and immunology. January 26, 2017 Vladimir Vladimirovich Putin awarded Khavinson Vladimir Khatskevich the Order of Friendship for his great contribution to the development of public health, medical science and many years of conscientious work.
Proteins are known as important building blocks in all kinds of living organisms. They consist of various amino acids that are connected by so-called peptide bonds to form a chain. The sequence of these amino acids determines their function.
Amino acid chains consisting of fewer than 100 ‘links’ are called peptides. The tiny peptides – each of them no longer than 1 nm – are individual short chains of amino acids. Depending on the number of their constituents, they are described as dipeptides (two), tripeptides (three), oligopeptides (up to 10 amino acid residues) and polypeptides (for 100 amino acid residues). While proteins are macromolecular substances, peptides belong to the microcosm, i.e. nano world, due to their tiny size.
Peptides fulfill a signal function in the body by transferring biological information from one cell to the other and by optimizing their performance.
The main types of peptide are:
- protein hormones – hormone from the hypothalamus, pituitary, somatotropin, prolactin, adrenocorticotropic hormone, melanotropin, pancreotropic and thyroid hormone, glucagonoma;
- neuro-peptides – hormones that are formed in the central and peripheral nervous system; they regulate physiological processes in the body;
- immunological hormones with defensive functions, and
- peptide-like bioregulators that control cellular functions.
The human body is able to form proteins. This process is called protein biosynthesis. Any disturbance will lead to illness and signs of decrepitude. But organic aging is also caused by an inhibition of protein development. After all, the organs suffer defects and damage as soon as the peptides no longer monitor the cells correctly.
Complexes comprising of peptide bioregulators are called Khavinson peptides in honor of their discoverer. They are natural peptides that were initially obtained from animal organs. Today they are manufactured synthetically.
The researchers initially conducted animal trials by administering peptide bioregulators obtained from the organs of calves. Elevated protein synthesis was then identified in the bodies of the test animals. Long-term application of the peptide bioregulators increased the mean life expectancy of the animals by 20 to 42.5%, sometimes beyond a normal, commonly observed lifespan.
The Khavinson peptides were ready for testing on older people after successful completion of the animal trials. The biannual administration of peptide bioregulators led to a significant reduction in mortality compared to the control group, which received polyvitamins.
Vladimir Khavinson was determined to heal his parents, so he included them as participants in his trials. His mother Anna Khavinson had already experienced a deterioration in eyesight due to her type II diabetes, while his father Khazkel Khavinson had suffered a stroke as a result of arteriosclerosis. His mother’s vision was restored after taking the peptides obtained from the retinas of calves. A special peptide bioregulator was produced to treat his father, leading to a complete restoration of his bladder function without requiring surgical intervention. As a result, his father lived for 30 years longer than the doctors had predicted. Over 80 years old, his mother does not have a single grey hair, continues to move independently and even tends to her own garden.
How is this possible? The Khavinson peptides act on a cellular level to improve cell activity and therefore the body as a whole. They support ongoing treatment, help in the restoration of various internal organs, and inhibit the aging process. They therefore present the opportunity to extend life and to fight many illnesses without side-effects. In this respect, peptide preparations have no adverse effects or toxic influences.
Additional research has confirmed that various types of peptide only act on certain organs, e.g. peptides formed in the liver can only affect the liver, while heart peptides will only influence the heart, etc. This is why each organ requires a matching peptide.
The peptide bioregulators are manufactured in natural (Zitomax) and synthesized (Zitogene) types. They are produced in the following form: as tablets, liquid peptides, dietary products, crèmes, ointments, herbal teas, decorative cosmetics and as care products for the oral area, etc.
Average life expectancy in developed countries is approximately 80 years. A large proportion of our energy is devoted to the protection of the organism against harmful environmental influences, stress and radiation. Because of this permanent drain on energy, our genetic structure changes, a situation which then accelerates the aging process. As a result of this, our life expectancy can be reduced by up to 40%.
Our current scientific capabilities allow us to control the aging process using peptides that influence the organism’s bioregulation system. These peptides possess remarkable tissue-specific properties and exert positive effects on the organs from which they are extracted. They play an important role in the exchange of information between cells of the immune, nervous and endocrine systems, in the reconstruction of organs and tissues, in functional regeneration, and in the regulation of gene activity. During this process these short peptides become bound to precisely defined sites in the genes before these data-containing structures within the DNA molecules are transcribed.
Professor Khavinson, a world-renowned gerontologist at the University of St. Petersburg who specializes in bioregulation and gerontology, was the first scientist to produce these peptides in a natural way. His innovative and highly effective technology has enabled the extraction these peptides from the tissues of young animals. Since the peptide bioregulators are not converted within the digestive system, they are highly compatible for everyone. No side effects have been observed, since the peptides are proteins which are also produced by the human body and which are therefore not treated as alien. Because of their small size, they act very rapidly and are considered inimitable due to their extraordinary and unique effect. Approximately 15 million people have used them in recent years, and feedback has been 100% positive.
As we get older, a peptide deficiency develops along with restricted protein synthesis, so that wear occurs in both the individual tissues and the whole organism. This then accelerates the aging process. To ensure that all cells can operate without any limitations, a certain quantity of peptides is required to maintain gene function at an optimal level. Peptides that are active in particular cells are also synthesized by these cells. Along with general performance of the body’s cells, peptide production also decreases with old age, which in turn has a negative effect on cell function. This results in a progression of tissue degeneration. The use of short peptides is therefore one of the most important innovations in modern medicine. By stimulating the proliferation and regeneration of tissues and increasing the cell count, the aging process can be decelerated by up to 40%.
A next significant and unique benefit is the anti-tumor effect within the body which arises from the contribution of peptides towards cellular regeneration and the harmonization of cyclic processes. The use of peptides is currently seen as a truly uncompromising solution for the prevention of tumor disease. At the same time the capacity for tissue-regenerating, regular cell division is also increased, which has a positive effect on the body as well.
This means that these peptides are identical in both animals and humans. Their capacity to normalize protein synthesis was proven long ago. We also know that the cell takes up no more peptides than it actually needs. The natural peptides act uniformly, because the tissue only provides feedback once enough peptides have accumulated to compensate for any existing deficiency. Only then do the cells return to a normal function.
This procedure has been scientifically proven to extend a person’s life. Many people in the US alone required cell therapy in 2000: for patients with cardiovascular disease – estimated at 5,800,000 individuals, autoimmune diseases – 30,000,000 people, diabetes mellitus – 12,000,000 people, osteoporosis – 10,000,000 people, oncological pathologies – 8 200,000 people, Alzheimer’s disease – 5,500,000 people, Parkinson’s disease – 5,500,000 individuals, severe burns – 300,000 people, spinal cord damage – 250,000 people, and malformations – 150,000 people. Similar findings have also been observed in other countries. The use of a complex of peptide bioregulators greatly reduces the risk of even becoming included under these statistics.
Messe CPhI Worldwide 2017
Peptiline GmbH and Khavinson’s Peptides.
Biography of Professor Khavinson and his research on peptides.
Biography of Professor Khavinson and his research on peptides.
Michael Fossel on Aging and the Telomerase Revolution